Methylation & folate
MTHFR — How your body turns folate into the active form it can use.
MTHFR carries the instructions for an enzyme that turns the folate in your food into its active form. A common version of this gene slows that enzyme down. When it runs slower, a compound called homocysteine can build up a little, and the body's wider methylation work — used to build DNA and brain chemicals — has less active folate to draw on.
What it influences
The honest picture.
- Runs the step that makes active folate (5-MTHF).
- Feeds the methylation cycle your body uses every day.
- Its effect is strongly shaped by your diet and B-vitamin status.
Grounded in public, peer-reviewed data: ClinVar · gnomAD · GWAS Catalog. Effect sizes vary between people, and your daily habits usually matter more.
What Indaga does with it
Indaga reads your MTHFR result and uses it to annotate your plan — for example, which form of folate the research favours for you, and when to take it. It does not diagnose anything, and it will not turn a gene result into a health score. If your file does not cover this variant, Indaga says "Unknown" instead of guessing.
What you can do
Research supports favouring active methylfolate and methyl- or hydroxy-B12 over synthetic folic acid, plus folate-rich foods like leafy greens, legumes and eggs. Indaga suggests options matched to your data — it is not a treatment.
The honest bit
Indaga annotates. It does not diagnose.
A gene result is context, not a verdict. Indaga uses MTHFRto annotate the timing and choices in your daily plan — never to predict or diagnose a disease, and never as a red or green health grade. If your DNA file does not cover this variant, you see “Unknown,” not a guess.
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Indaga is a wellness and education product — not a medical device. It does not diagnose, treat or cure any condition. Talk to a qualified clinician for medical decisions.